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The article sets the threshold at sustained systolic elevations above 10 mmHg, or the appearance of symptoms such as headache, palpitations, or chest discomfort
[16] Patients switching from semaglutide to tirzepatide, or vice versa, should apply the same ibuprofen caution during the dose-escalation phase of whichever agent they are using
This has led researchers and clinicians to investigate whether newer anti-obesity medications, including GLP-1 receptor agonists like Zepbound (tirzepatide), might offer therapeutic benefits for patients with MASLD beyond their primary indication for weight management and glycemic control
However, weight loss itself, whether achieved through medication or lifestyle change, leads to reductions in both fat mass (FM) and lean mass (LM) , meaning that muscle and bone are often lost alongside fat
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