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Results Evidence suggests that GLP-1RAs mitigate psoriasis severity through systemic effects, including weight loss and improved glycemic control, and local immunomodulation, such as the regulation of invariant natural killer T (iNKT) cells and AMPK activation in psoriatic plaques

The final signature at iteration 153 included two clinical features (age and BMI) and six metabolites: histidine, succinic acid, carnitine, docosatrienoic acid, hexadecanedioic acid and creatinine, all contributing positively to the prediction of PFS (Fig

The oral route of drug delivery is challenging for peptides because the GI tract is specifically designed to break down proteins and peptides into their constituent amino acids for absorption