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Most GLP-1RAs, aside from a new oral formulation of semaglutide (Rybelsus tablets), are administered subcutaneously via pen-like devices (once daily to once weekly) due to poor oral bioavailability, and all are renally excreted 1
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The secret to this profitability is how the device fits into the broader business ecosystem
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![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
