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IGF-1 is a primary mediator of growth hormone (GH), with growth-promoting effects on most cells and tissues including skeletal muscle, cartilage, bone, liver, kidney, nerve, skin, hematopoietic, and lung [1]
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FOXO4 knockdown resulted in increased levels of p53 and Ser15-phospho-p53, but paradoxically decreased the level of p21
This fetal programming could be involved in, at least, two pathological conditions in later life, as insulin resistance and hypertension
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