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For both sample clustering and gene clustering, we applied spearman distance as similarity measure between every pair of objects in the dataset, then we generated binary hierarchical cluster tree using linkage function which employs average method for computing the distance between clusters

This work was supported by the National Institute for Health and Care Research Maudsley Biomedical Research Centre

Loss of PTEN is associated with resistance to anti-PD-1 checkpoint blockade therapy in metastatic uterine leiomyosarcoma