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One possible explanation for the similar effects on weight loss observed with both GIPR agonism and antagonism might be that chronic pharmacological GIPR activation induces functional antagonism in a subset of neurons through receptor desensitization, as seen in adipocytes, isolated pancreatic islets and mouse neuroblastoma Neuro2a cells 36,37
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But for the 29 million Americans who currently take a semaglutide Ozempic or Wegovy or a terzapetide Mounjaro or Zepbound the results are mixed
318 : 639 Farlow MR, Lahiri DK, Poirier J, Davignon J, Schneider L, Hui SL
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