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Systemically, when they are absorbed orally they can provoke vasodilatation in massive doses, the arsenic can provoke deleteriores effects in the cardio-circulatory system, like destruction of the capillaries and arterioles, as well as myocardic necroses
These medications should be used with caution in patients with significant gastrointestinal disease, such as gastroparesis, as noted in product SmPCs
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