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Older Adults: As we age, stomach acid production can decrease, making B12 absorption more challenging
Under normal physiological conditions, small amounts of 5-oxoproline are derived from gamma-glutamyl-cysteine by the action of gamma-glutamyl cyclotransferase (63)
The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents
Understanding this mechanism matters because it explains why most GI side effects are dose-dependent, temporary, and manageable through titration strategies
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