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HLC cultures were incubated with conventional probe substrates for CYP3A4 (6 M midazolam), CYP2C9 (10 M diclofenac), and CYP2D6 (10 M dextromethorphan) for 2 hours

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Thalidomide a drug, perhaps known more for its controversial 1950s history as a sedative for pregnant women with morning sickness, which was withdrawn after it was found to lead to severe skeletal birth defects was repurposed and approved by the FDA about 60 years later for use in combination with dexamethasone in patients with newly diagnosed multiple myeloma

Studies have found that 12-58% of ergogenic supplements contain contamination, 30% of peptide products have incorrect amino acid sequences, and 65% exceed safe endotoxin thresholds