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Unlike small-molecule drugs that tolerate moderate temperature variation, peptides rely on precise three-dimensional folding to interact with cellular receptors
As a result, pyridoxine deficiency can lead to relevant neuropsychiatric manifestations, such as reduced neurotransmitter synthesis, depression, epilepsy, premature aging of neurons, paresthesias, cerebrovascular diseases, cognitive impairment and carpal tunnel syndrome (4, 6, 11, 1618, 20, 58) In contrast, pyridoxine may have therapeutic potential for treating depression or aggressive behavior, since pyridoxine plays a crucial role in the tryptophan-serotonin pathway (61, 62)
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GhatiADamPTasdemirDKatiASellamiHSezginGCet alExogenous pulmonary surfactant: a review focused on adjunctive therapy for severe acute respiratory syndrome coronavirus 2 including SP-A and SP-D as added clinical marker
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