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and placebo (470 mg cellulose)
In a small Phase IIb placebo-controlled trial involving 71 participants with obesity and MASH-related compensated cirrhosis, semaglutide 2.4 mg once weekly for 48 weeks did not significantly improve liver fibrosis or achieve MASH resolution compared with placebo [37]
Methylcellulose (Citrucel) is less likely to cause gas and bloating than psyllium, making it better tolerated for tirzepatide users already dealing with GI sensitivity
Its status as the reference retinoid is earned: few topical anti-aging actives have been validated to the same standard
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