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The combination of these two receptors is what separated tirzepatide from earlier single-agonist medications like semaglutide
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( Figure 5 ) Briefly, SGLT2i inhibits the SGLT receptors in the proximal tubule, which inhibits the reabsorption of glucose from primary urine, resulting in glycosuria and a decrease in HbA1c and fasting glucose levels (34)
The efficacy of oral semaglutide in reducing glycated hemoglobin (HbA 1c ) and body weight in individuals with T2D has been demonstrated in the phase 3 PIONEER 9 and 10 clinical trials [3, 4]
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