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Peng J, Dong Y, Luo Y, et al
Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death
Combined research protocols allow investigators to examine whether co-administration produces additive effects on tissue-repair-relevant endpoints compared to either compound studied in isolation
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