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Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial

This opens protocol design options and raises mechanistic questions about how a 15-amino-acid peptide survives the GI tract with sufficient intact molecule to produce systemic effects (or whether the observed effects are primarily local GI-tract actions)

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Risk factors for Korsakoffs syndrome include repetitive thiamine deficiency episodes and genetic predispositions, such as mutations in the transketolase enzyme that reduce its affinity for TPP (5)