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Importantly, results also demonstrated that the enhancement effect of LASSS on the c-met binding-affinity of HGF is consistently maintained, even after the removal of un-reacted free LASSS (and any degradation products of LASSS), by an interaction between HGF and LASSS or potentially by specific chemical modification of HGF at a high molar ratio of 1:8000 to HGF (over 1:4000)
Similar protective effects were observed with DFO (Fig
Pharmaceutics 5 , 220231 (2013)
However, the BHMT reaction is limited to the human liver and kidney since BHMT is expressed primarily in the hepatocytes and kidney cortex (Sunden et al., 1997)
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