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When nucleoid turnover and endolysosomal disposal are compromised, mtDNA and inner membrane-associated immunostimulatory species accumulate in aberrant location and chronically activate cytosolic DNA sensing and inflammasome pathways, including cGAS-STING and NLRP3 pathway, thereby biasing myeloid and stromal compartments toward type I interferon and IL-1 family responses (144,157,158)
All subjects were housed in individual cages with ad libitum access to food and water
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Translational stroke research on blood-brain barrier damage: challenges, perspectives, and goals
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