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In the A Study of Tirzepatide [LY3298176] in Participants with Type 2 Diabetes (SURPASS-2) trial, tirzepatide (5 to 15 mg) was superior to 1.0 mg of semaglutide in improving both HbA1c and body weight [5], in contrast to our results
The therapeutic benefit remains stable while the uncomfortable adjustment phase endsa distinction many patients find encouraging as they push through the first few weeks
However, concerns exist regarding the impact of GLP-1 RAs on lean mass, particularly with respect to true skeletal muscle mass
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