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Early trial findings have sparked interest, but they also raise important questions about how these results should be interpreted outside controlled studies

In reality, up to 70% of patients stop GLP-1 treatment within a year most often due to: High cost (GLP-1s can cost $1,000+ per month without insurance) Loss of insurance coverage for weight loss treatment Side effects such as nausea, diarrhea, constipation, or fatigue A Misconceptions some patients stop once they lose initial weight, believing they no longer need the medication 2

Histology and immunohistochemistry in humans Paraffin-embedded ileal samples were cut into 4-m sections and stained with hematoxylin and eosin (H&E)

Steady energy and fewer cravings