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Similarly, in chronic myeloid leukaemia (CML), co-inhibition of Trx1 and glutamate-cysteine ligase may serve as a therapeutic strategy for both imatinib-sensitive and drug-resistant patients by triggering ferroptosis (75)

Every piece of clinical evidence supports it

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Brain Sci 6:31 Sanadgol N, Barati M, Houshmand F, Hassani S, Clarner T, Golab F (2020) Metformin accelerates myelin recovery and ameliorates behavioral deficits in the animal model of multiple sclerosis via adjustment of AMPK/Nrf2/mTOR signaling and maintenance of endogenous oligodendrogenesis during brain self-repairing period