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Taken together these results support the safety of IDN 5933 at the used doses for a duration of 6 months
Simultaneous quantification of these two oxidized metabolites by electrochemical HPLC assay demonstrated that human P450 2E1 selectively oxidizes APAP to NAPQI (determined as glutathione conjugate, GS-APAP), whereas human P450 2A6 selectively oxidizes APAP to 3-OH-APAP (Chen et al., 1998)
8k, yellow bars), and a strong increase in UCK2 expression (Fig
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