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These medications work through several mechanisms, including slowing gastric emptying (though this effect may attenuate over time), acting on appetite centers in the hypothalamus, and enhancing feelings of fullness

Human kidney and liver gluconeogenesis: evidence for organ substrate selectivity

Evidence from RCTs has shown that the benefits of each agent are maintained regardless of concomitant use [118,119], without a significant increase in the risk of hypoglycemia or AKI [120,121]

A researcher choosing between them is choosing between two fundamentally different pharmacological strategies for addressing the same condition