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Aronne LJ, et al
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IL-4 secreted by activated T cells has anti-angiogenic effects by inhibiting VEGF production in RA FLS, which helps relieve RA ( + T cells population ( via activation of protein kinase C (PKC) / II and ERK-1/2, with concomitant down-regulation of the NF-B/p65 pathway ( via activating Smad-2/3 in RA ( ( Figure 1 )
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