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It was also somewhat reassuring to see that heart failure rates were lower with SGLT2 inhibitors, as one would expect, he said, because these agents have been shown to significantly reduce the risk of hospitalization for heart failure in multiple outcome trials, whereas GLP-1 receptor agonists beneficial CV effects appear to be more limited to MACE reduction. The higher rates of discontinuation with GLP-1 receptor agonists is also not a surprise, since patients experience more gastrointestinal tolerability issues with these agents (mainly nausea), which can be mitigated in the majority of patients with appropriate education and close follow up but is not done consistently

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Along with weight loss, Faubions study found that both groups of women on semaglutide drugs showed improvement in heart health measures like A1C (a marker for diabetes) and blood pressure, although the women who were also on MHT did see more significant improvement in their overall cholesterol levels

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