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Description

Even at modest dosages, MTX can cause hepatic fibrosis and cirrhosis as a significant adverse effect

This strategy holds greater potential for future clinical translation

There additionally exists a safety argument for using MRAs in combination with SGLT2 inhibitors to reduce the risk of hyperkalemia, since the latter medication class has a modest potassium lowering effect as suggested by a recent post hoc analysis of MRA use in DAPA-HF [106]