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Authors identified a gene set (Core Aging Signature, CAS) composed of 95 upregulated and 248 downregulated genes, whose expression suggested that quiescent NSCs undergo early transcriptomic alterations already at middle age, indicating early molecular aging, in agreement with previous data ( ret/ret mouse, which indeed showed pericyte decrease associated to infiltration of T cells and reduced number of neuroblasts and immature neurons (DCX-positive) in the dentate gyrus
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