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Those are all relevant and very important questions
It is well known that the interaction of chronic pain and anxiety in ICU patients at multiple levels, such as sepsis symptoms, hospital environment factors, and frequent bedside vital signs monitoring and examinations, can lead to sleep disorders, which highlights the importance of sedation and analgesia treatment, which can activate the sympathetic nervous system and hypothalamic-pituitary-adrenal axis
A positive FRAT result may raise the question of leucovorin treatment
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