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As a board-certified family physician and aesthetic expert with specialized training in obesity medicine, Dr

In clinical trials, participants using Zepbound achieved an average weight loss of approximately 20.2% over 72 weeks, while those on Wegovy experienced about a 13.7% reduction

This revealed that ghrelin robustly activates ARC AgRP/NPY neurons as soon as 30 s after its systemic administration, while it robustly inhibits ARC POMC neurons after a 15-min delay suggesting an indirect effect [145]

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