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In murine models, it was observed that human ApoE4 knock-in (KI) mice display increased A deposition compared to human ApoE3-KI mice (Holtzman et al., 2000), while human ApoE2 expressing mice showed a marked reduction in A deposition (Fagan et al., 2002)
The mixture is being studied for musculoskeletal regeneration, but the human data is still not enough
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