Certain agents, including semaglutide and liraglutide, are additionally indicated for longterm weight management in individuals with obesity or overweight, typically in the presence of at least one weightrelated comorbidity
Weight loss with oral semaglutide 14 mg, the highest approved dose, is approximately 8% to 10% of body weight over a similar time frame where injectable semaglutide achieves 15%
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Of the 12 medications studied, seven are single agonists of GLP-1, four are dual agonists (including tirzepatide and three investigational agents that act on the GLP-1 and glucagon pathways), and one (retatrutide) is a triple agonist of the GLP-1, GIP, and glucagon pathways