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The point isnt stimulationits efficiency
The aggressive titration tail in the 12 mg arm of the Phase 2 trial was strongly associated with higher rates of transient gastrointestinal adverse events, which is why researchers generally favor slower escalation when tolerability is prioritized
The studied dosing starts low (about 2 mg weekly) and is increased roughly every four weeks to a target dose, with 12 mg being the highest dose in the main Phase 2 obesity trial
Afaghi 2012
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