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- Medical necessity: Evidence that the adult patient's condition meets the specific criteria for using this drug, often including a history of inadequate response to or intolerance of other conventional therapies like methotrexate or NSAIDs

Cons: Not FDA-approved for any indication, and as of an October 2023 FDA action, ineligible for legal compounding for human use, so supply is limited to research-use-only sellers with variable purity and quality control