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The study of levels from redox-active elements in cerebrospinal fluid of amyotrophic lateral sclerosis patients carrying disease-related gene mutations shows potential copper dyshomeostasis

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This leads to a dysfunction in ATP-dependent ion transport processes, culminating in increased intracellular and mitochondrial calcium levels (calcium overload), cellular swelling, rupture, and cell death via various pathways including necrosis, apoptosis, and autophagy

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