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This suggests that GLP-1 RAs may be most appropriate for adolescents with established obesity who have not responded to comprehensive lifestyle interventions
For those with a BMI of 2530 kg/m 2 , the drugs are better positioned as preconception metabolic optimization tools, with an emphasis on post-discontinuation maintenance and washout strategies
The most interesting thing about the study is perhaps not only the results themselves, but what they potentially tell us about the GLP-1 system and the brain
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