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Estos estudios son los llamados STEP (Efecto del tratamiento con semaglutida en personas con obesidad) y ya estn completos

A 2026 review in Biological Psychiatry highlighted how GLP-1 signaling extends throughout the brainstem, limbic system, and mesolimbic pathways

Semaglutide to Tirzepatide: Switching Guide Switching from semaglutide to tirzepatide is one of the most clinically supported medication transitions in GLP-1 weight loss treatment

While exposure to long-term therapy is of potential concern, it is uncertain whether drug exposure to GLP-1 receptor agonist therapies for shorter durations is of any clinical consequence 28