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This inhibition preserves cellular NAD+ levels by reducing their consumption, simultaneously increasing GLUT4 transporter expression and activating sirtuin 1, known as the "longevity gene." The compound exhibits high membrane permeability and selectivity without affecting related methyltransferases or NAD+ salvage pathway enzymes, creating targeted metabolic effects while maintaining cellular safety
The existing data strongly suggests that achieving those profound effects requires careful titration to much higher maintenance doses, likely in the 8mg to 12mg range
27 FangZ.ChenS.ManchandaY.BitsiS.PickfordP.DavidA.et al (2020)
Shah KB, Fields DA, Pezant NP, et al
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