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defensin alpha 1 (DEFA1), IL-8 (CXCL8), Fc gamma receptor IIIb (FCGR3B), cytochrome b-245 alpha chain (CYBA), and subunit of NADPH oxidase neutrophil cytosolic factor 1 (NCF1)

12.2 Pharmacodynamics Hemodynamics Following administration of therapeutic doses to patients with hypertension, amlodipine besylate produces vasodilation resulting in a reduction of supine and standing blood pressures