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Absolute and Relative Contraindications Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use GLP-1 receptor agonists due to thyroid C-cell tumor risk observed in animal studies

This leads to increased drug accumulation in cancer cells, which can enhance the effectiveness of chemotherapy agents like doxorubicin and cyclophosphamide (Tew and Gat, 2001

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