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Licensed alternatives for weight management, including semaglutide (Wegovy) and liraglutide (Saxenda), are available through regulated NHS and private pathways following NICE appraisal

A study by Xcenda found that only about 40 diabetes, weight loss, endocrine, and metabolic drugs had been excluded from at least one pharmacy benefit manager (PBM) formulary in 2014

The sample size of 30 patients in each group was required to achieve a power of 90% with alpha = 0.05 to detect a medium to large effect size of 0.86 in post-operative troponin I level

doi:10.1038/cdd.2009.107 Kavouras JH, Prandovszky E, Valyi-Nagy K, et al