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Federici M, Menghini R, Mauriello A, Hribal ML, Ferrelli F, Lauro D, et al

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Ipamorelins selective GHS-R1a agonism drives GH granule exocytosis from somatotrophs through Gq/11-PLC-IP3-calcium mobilisation , the identical intracellular signalling cascade engaged by non-selective first-generation GH secretagogues and but does so without producing the off-target receptor engagement at pituitary lactotrophs and corticotrophs that drives prolactin and cortisol co-secretion following GHRP-6 and GHRP-2 administration

Using bacteriostatic water rather than sterile saline extends the stability of the reconstituted solution to approximately 30 days under refrigeration