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The process of cellular senescence involves multiple factors, including DNA damage, telomere shortening, and epigenetic changes, which lead to cell cycle arrest and ultimately result in cellular senescence (Zhang et al., 2024)
long-term health and aging-related outcomes
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For instance, the normal aging process results in impaired GSH synthesis capability resulting in as much as a 50% reduction in available GSH in tissues and fluids [16]
Nature Medicine, 29(11), 2909-2918
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