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Lgr5 -positive cells exhibiting varying degree of stem cell properties have also been found in the stomach (Barker et al., 2008) and mammary gland (de Visser et al., Lgr5 -positive cells continuously give rise to new hair follicle cells, another Lgr family receptor Lgr6 , marks a different, Wnt-independent, stem cell population that replenishes the epidermis and sebaceous glands (Barker et al., Lgr5 - and Lgr6 -expressing cells also contribute to wound healing in the skin, while Lgr6 -positive progeny alone are responsible for establishing long-term repair of all components in the skin

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Further evidence comes from a randomized, double-blind, placebo-controlled Phase Ib clinical trial that also evaluated the efficacy and safety of setmelanotide in obese patients harboring heterozygous LOF variants in MC4R (either complete or partial LOF

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