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A major source of preproglucagon and, thus, GLP-1, is found in PC1/3-expressing neurons in the caudal area of the medial nucleus of the solidary tract (NTS) and, partially, the area postrema, which both belong to the dorsal vagal complex (DVC)
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Its profile has supported research into coordinated endocrine signaling, metabolic adaptation, weight-related biology, glucose regulation, and energy expenditure
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