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Prescription medicines require evaluation and a valid prescription from a licensed clinician
Some women report labial wrinkling and sagging after losing weight with the help of weight loss drugs, the Daily Mail reported
However, in cosmetic use, claims must remain focused on brightening or evening skin tone rather than altering natural pigmentation
For pigment specifically, a randomized, vehicle-controlled trial found topical tretinoin significantly improved melasma (a randomized vehicle-controlled trial showing topical tretinoin improves melasma), and a separate vehicle-controlled study confirmed the benefit specifically in patients with darker skin (a vehicle-controlled trial of topical tretinoin for melasma in darker skin)
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