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Within each dose cohort, 8 participants will be randomized in a 3:1 ratio to nimacimab (n=6) or placebo (n=2)
Under the GLP-1 Bridge Program, Medicare will cover Wegovy specifically for weight loss - not just for diabetes management
However, safety depends on several factors: injection site rotation to avoid lipodystrophy, adequate hydration (both agents can increase fluid demand), and monitoring of B vitamin status since semaglutide may affect nutrient absorption slightly during rapid weight loss phases
doi:10.3389/fpls.2014.00805
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