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1 , 26 Medical ozone acts indirectly by triggering an Nrf2/Keap1/ARE-mediated antioxidant response, which upregulates transcription of genes encoding various antioxidant and detoxification enzymes, including heme oxygenase-1, NADH:quinone oxidoreductase-1, and glutathione-synthesizing enzymes

The main reasons people use HCG without FDA approval are for weight loss and for boosting testosterone

Its use in moderate renal impairment (eGFR 30-45 mL/min) requires careful assessment, potential dose reduction, and frequent monitoring of kidney function