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Effects on Non-Alcoholic Fatty Liver Disease Non-alcoholic fatty liver disease (NAFLD) is a metabolic stress liver injury closely related to IR and genetic variations
These medications are most effective when combined with a healthy diet and exercise
GLP-1R activity also promotes the transactivation of epidermal growth factor receptor (EGFR), which then signals through phosphoinositide 3-kinase (PI3K) and insulin receptor substrate-2 (IRS-2), and subsequently activates extracellular-signal-regulated kinase 1 and 2 (ERK1/2) and nuclear translocation of PKC to mediate -cell proliferation and differentiation (110, 114)
This could explain why tirzepatide was better tolerated despite targeting an additional receptor
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