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Additionally, the risk of sustained doubling of serum creatinine, end-stage renal disease, and renal death was lower in the canagliflozin group ( Subsequent studies, such as CREDENCE, DAPA-CKD, and EMPA-KIDNEY, were specifically designed to investigate the renoprotective effects of SGLT-2i
,[21] is more stable in blood plasma than GSH, and enters the cells directly, where it is converted to reduced glutathione by the abundant cytoplasm thioesterases
Missing doses or varying the time by several hours each day creates peaks and valleys in blood concentration that reduce overall effectiveness and can worsen side effects like nausea
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