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In addition, there are precautions for their use in people with pancreatitis and diabetic retinopathy, the incidence of which is generally increased in T2DM

This effect directly opposes Wegovy's appetite-suppressing action, potentially reducing the caloric deficit necessary for weight loss

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The bottom line : theres currently no evidence that GLP-1 agonists enhance actual athletic performance in humans, and there are plausible reasons to worry they could hinder performance by reducing muscle and interfering with fuelling (more on that below)