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Distribution then occurs rapidly throughout the cortex, hypothalamus, and other brain regions

A dimer obtained by inserting a Cys-Cys linker between two units of KPV, (CKPV) 2 , inhibited tumor necrosis factor-alpha (TNF-) production by lipopolysaccharide (LPS)-stimulated human leukocytes with potency similar to the stable -MSH analog [Nle4-dPhe7]--MSH (NDP--MSH) and effectiveness greater than KPV