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Semaglutide: A Closer Look Semaglutide is primarily known as a GLP-1 receptor agonist, a drug class initially developed to treat type 2 diabetes by mimicking an intestinal hormone that helps control blood sugar
The FAERS database undergoes quarterly updates, with all data sets publicly accessible through the FDAs Open Data portal ( Data extraction and processing The FAERS database architecture incorporates seven distinct data tables, each serving specific pharmacovigilance functions: (1) DEMO (patient demographic and administrative information), (2) DRUG (medication-related data), (3) REAC (adverse event reports), (4) OUTC (patient outcomes), (5) RPSR (report source information), (6) THER (temporal drug administration data), and (7) INDI (therapeutic indications)
Bulk RNA sequencing revealed that gene expression changes were most pronounced in the MBH, where RAMP1/3 KO mice treated with sCT showed extensive differential expression of over 1,700 genes, while WT mice exhibited comparatively minor transcriptional shifts
